The Handbook of Electrophysiology: A Practical Guide for Neurophysiologists

Book info: The Handbook of Electrophysiology: A Practical Guide for Neurophysiologists (Hardcover, 824 pages) – World Scientific Publishing Company, 2026. Language: English.

This book serves as an extensive resource on electrophysiology, offering a detailed exploration of techniques used to study ion channels, synaptic function, and neural circuits. It provides in-depth descriptions of various patch-clamp recording methods, including single-channel, whole-cell, perforated patch, and in vivo approaches. In addition to patch-clamp techniques, the book covers intracellular sharp electrode recordings, extracellular electrophysiology, and high-density multi-electrode arrays, ensuring broad applicability across diverse experimental settings.

A key strength of this book is its focus on diverse cell types and models, including neurons, glial cells, immune cells, organoids, human iPSC-derived neurons, and intracellular organelles. It also explores advanced techniques such as robotic automation, two-photon targeted patch-clamp, and optogenetics-based circuit mapping, ensuring its relevance to contemporary neuroscience research. Designed for both novice and experienced researchers, the book provides guidance on fundamental equipment, experimental design, and troubleshooting. It serves as an essential resource for neuroscientists, electrophysiologists, and biomedical researchers investigating electrical activity at cellular and network levels. Editorial Reviews About the Author Dr Duguid studied Pharmacology as an undergraduate before completing his PhD at the London School of Pharmacy with Dr Trevor Smart, working on inhibitory synaptic plasticity in the cerebellum. He did his postdoctoral research with Dr Michael Häusser at University College London, where he investigated sensory information processing in single cerebellar neurons in vivo. Dr Duguid started his lab at the Centre for Discovery Brain Sciences, University of Edinburgh in 2009. The main research interest of the lab is to understand the neural circuit mechanisms that underpin flexible motor control.

Dr Scimemi studied Biology at the University of Pisa, and completed her PhD in Biophysics at the International School for Advanced Studies (SISSA/ISAS, Trieste, Italy), working with Drs. John G Nicholls and Enrico Cherubini. She completed her postdoctoral internships at University College London, with Dr Dimitri M Kullmann, and at the National Institutes of Health in Bethesda (MD), wth Dr Jeffrey S Diamond. During this time, she used in vitro patch clamp recordings to understand how neurotransmitter diffusion away from the synaptic cleft alters information transfer in small hippocampal circuits. She established her lab at SUNY Albany in 2013. Her lab is interested in understanding how neurons and astrocytes shape synaptic function and neuronal activity in vitro and in vivo.

Dr Wanaverbecq earned his PhD in Pharmacology from University College London under Prof. D A Brown, studying calcium homeostasis in neurons. He trained as a postdoctoral fellow, first at University College London with Dr Dimitri Kullmann and later at the Biozentrum (Basel University, Switzerland) with Dr Anita Lüthi, investigating cholinergic modulation of GABAergic signaling and GABAergic subthalamic projections to the motor thalamus. In 2017, he established his lab at the Institut des Neurosciences de la Timone (Aix-Marseille University & CNRS UMR7289), focusing on a unique neuronal population near the medullo-spinal central canal, which interacts with the cerebrospinal fluid and serves as a novel component of the interoceptive sensory system in mice and non-human primates.