{"product_id":"stem-cell-and-growth-factor-delivery-vehicles-for-cartilage-repair-co-delivery-of-growth-factor-loaded-microspheres-and-human-adipose-stem-cells-in-a-gel-matrix-for-cartilage-repair","title":"Stem cell and growth factor delivery vehicles for cartilage repair: Co-delivery of growth factor-loaded microspheres and human adipose stem cells in a gel matrix for cartilage repair","description":"\u003cp\u003e\u003cstrong\u003eBook info:\u003c\/strong\u003e Stem cell and growth factor delivery vehicles for cartilage repair: Co-delivery of growth factor-loaded microspheres and human adipose stem cells in a gel matrix for cartilage repair (Paperback, 220 pages) – LAP LAMBERT Academic Publishing, 2012. Language: English.\u003c\/p\u003e\n Co-delivery of embedded growth factor-loaded microspheres and adult stem cells in a hydrogel matrix was studied for its potential as a cell-based therapeutic strategy for cartilage regeneration in partial thickness chondral defects. A photopolymerizable N-methacrylate glycol chitosan (MGC) was employed to form an in situ gel that was embedded with two formulations of growth factor-loaded microspheres and human adipose-derived stem cells (ASC). The polymeric microspheres were used as a delivery vehicle for the controlled release of growth factors to stimulate differentiation of the ASC towards the chondrocyte lineage. Bone morphogenetic protein-6 (BMP-6) and transforming growth factor-b3 (TGF-b3) were delivered at 5 ng\/day at highly bioactive states. The ratio of collagen type II to I per cell was significantly higher for ASC chondrogenesis induced by the sustained release of BMP-6 and TGF-b3 in MGC gels than that of non-induced ASC or with soluble growth factor administration in the culture media. Thus, the co-delivery of growth factor-loaded microspheres and ASC in MGC gels successfully induced ASC chondrogenesis and is a promising strategy for cartilage repair.  ","brand":"Abby Sukarto","offers":[{"title":"Default Title","offer_id":46070567174378,"sku":"9783659229817","price":98.75,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0714\/5301\/6298\/files\/817sLK06bAL._SL1500.jpg?v=1781270988","url":"https:\/\/textbookme.store\/products\/stem-cell-and-growth-factor-delivery-vehicles-for-cartilage-repair-co-delivery-of-growth-factor-loaded-microspheres-and-human-adipose-stem-cells-in-a-gel-matrix-for-cartilage-repair","provider":"TextbookMe","version":"1.0","type":"link"}